| LUC | Labor Unit Control | |
| LUC | Latinos United in Community | |
| LUC | Limit Unnecessary Confusion Life Under Control | |
| LUC2 | Lucino 2wd | |
| LUCA | Last Universal Common Ancestor | |
| LUCA | Learning Unique Creative Alternatives | |
| LUCA | Last Universal Cellular Ancestor | |
| LUCA | Local Update of Census Addresses | |
| LUCA | Local Update on Censuses Addresses | |
| LUCAS | Lancaster University Computer Assessment System | |
| LUCAS | Logwares Universal Commerce Application System | |
| LUCAS | Land Use Change Analysis System | |
| LUCAS | Learning and Understanding Children in All Societies | |
| LUCAS | Lund University Cardiopulmonary Assist System | |
| LUCAS | London Undergound Combined Access System | |
| LUCAS | London Underground Combined Access System | |
| LUCAS | Lasts Until Car Actually Starts | |
| LUCAS | Lund University Cardiac Assist System | |
| LUCAS | Lund University Cardiac Assist System | |
| LUCAS | Let Us Consider Adopting Strays | |
| LUCASIAN | Luc's Asian | |
| LUCB | Live Update Callback | |
| LUCC | Land Use/Cover Change | |
| LUCC | Lindenwood University Cultural Center | |
| LUCC | Land Use Coordinating Committee |
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